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KMID : 1128320070050010023
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Electrolytes & Blood Pressure
2007 Volume.5 No. 1 p.23 ~ p.27
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Effects of Antioxidant Drugs in Rats with Acute Renal Injury
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Bae Eun-Hui
Lee Jong-Un
Kim Soo-Wan
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Abstract
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Acute renal failure is mainly caused by ischemia/reperfusion (I/R) injury or nephrotoxic drugs, in which reactive oxygen species (ROS) may play an important role. Therefore, antioxidants are expected to decrease the vulnerability of renal injury associated with oxidative challenges. α-Lipoic acid (α-LA), potent antioxidant, could act as ROS scavengers, iron chelators and enzyme modulators. In rats with acute renal injury, dysregulation of aquaporin (AQP) water channels and sodium transporters has been noted. I/R injury or cisplatin induced marked down-regulation of AQP1, AQP2 and AQP3 water channels, and type-3 Na-H exchanger, Na,K-ATPase, and Na-K-2Cl cotransporters, in association with impairment of urinary concentration and tubular sodium reabsorption. Treatment with α-LA prevented the dysregulation of AQP channels and sodium transporters, along with improved urinary concentrating capability and renal sodium reabsorption.
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KEYWORD
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Aquaporins, Reperfusion injury, Sodium transporters, Thioctic acid
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